Computational and Quantitative Biology PhD

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Project Proposals XLII cycle 2026

Below is the list of proposed projects for the XLII CQB PhD Cycle.
Project title Tutor Abstract
Understanding the immune system using single-cell computational approaches Prof. Claudia Angelini
Istituto per le Applicazioni del Calcolo, CNR
📄 DOCX
Decoding the Functional Genome: An Integrated Genomics Platform Coupling Massively Parallel Assays with Single-Cell and Spatial Multi-Omics to Dissect Genotype-Phenotype Relationships Prof. Davide Cacchiarelli
Telethon Institute of Genetics and Medicine
📄 DOCX
Decoding Regulatory Amplifications in Pediatric Cancer through Computational Multi-Omics Prof. Mario Capasso
CEINGE Biotecnologie Avanzate Franco Salvatore
📄 DOCX
Genome foundation models in agriculture: Advancing plant genomics with Evo 2 Prof. Nunzio D'Agostino
Department of Agricultural Sciences, University of Naples Federico II
📄 DOCX
PROMetheus: AI-designed synthetic promoters for precision gene therapy of inherited retinal disease Prof. Diego di Bernardo
Telethon Institute of Genetics and Medicine
📄 DOCX
Digital twins of the human microbiome: Integrative metagenomic modeling from large-scale datasets Prof. Edoardo Pasolli
Department of Agricultural Sciences, University of Naples Federico II
📄 DOCX
Integrative bioinformatics for trans-omics networks representation and image analysis Prof. Antonio M. Rinaldi
Department of Electrical Engineering and Information, University of Naples Federico II
📕 PDF
Exploiting multiomics data in human disease model alignment Dr. Giovanni Scala
Department of Biology, University of Naples Federico II
📄 DOCX
Decoding the Dark Spliceosome: A Computational and Quantitative Framework to Discover and Functionally Classify Pathogenic snRNA Variants in Rare Genetic Diseases Prof. Marcella Cesana
Department of Advanced Biomedical Sciences, University of Naples Federico II
📄 DOCX
Analysis and Prediction of Challenging Genetic Variants Using Artificial Intelligence-Based Approaches Prof. Maria Vittoria Cubellis
Department of Biology, University of Naples Federico II
📄 DOCX
Deciphering the Lactate-Epigenetic Axis in Cancer Chemoresistance: The Role of H3K18 Lactylation in the DNA Damage Response Prof. Barbara Majello
Department of Biology, University of Naples Federico II
📄 DOCX
Chromatin-aware modelling and engineering of disorder in transcription factors Dr. Davide Mercadante
Department of Pharmacy, University of Naples Federico II
📕 PDF
RNA Hybrid AI Platform for Structural Observables and Dynamics Dr. Davide Mercadante
Department of Pharmacy, University of Naples Federico II
📕 PDF
A Computational and Quantitative Framework for Genome-Wide Reconstruction of Therapeutic Genome-Editing Outcomes Dr. Gennaro Gambardella
Telethon Institute of Genetics and Medicine
📄 DOCX
Mechanisms of 3D chromatin restructuring in healthy and pathogenic genomes Dr. Andrea Maria Chiariello
Department of Physics, University of Naples Federico II
📄 DOCX
A Multi-Omics Graph Neural Network Framework for Systematic Discovery and Drug-Oriented Validation of Synthetic Lethal Interactions in Triple-Negative Breast Cancer Prof. Alfonso De Simone
Department of Pharmacy, University of Naples Federico II
📕 PDF
Decoding the Fusobacterium surface glycocode in colorectal cancer: structure, host recognition and function Prof. Alba Silipo
Department of Chemical Sciences, University of Naples Federico II
📄 DOCX

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