Computational and Quantitative Biology PhD

Lecturers

• TBD

Time and Credits

This course amounts 6 ECTS (30 hours) 

Overview 

1. Alignments: Longest common subsequence, edit distance, global alignment, localvalignment. Substitution matrices: PAM and BLOSUM. Multiple alignments.
2. Motif search in genomic sequences: PWM, PSSM, pattern matching
3. Molecular phylogenetics: phylogenetic trees, genetic distance, tree building algorithms: clustering based methods and sequence based methods
4. Functional genomics and gene expression: microarray data and sequencing data, differentially expressed genes and statistical tests, functional analysis, and Gene Ontology over-representation
5. Algorithms for the analysis of next generation sequencing data: genome mapping, genome assembly, variant detection, gene expression quantification.

Schedule

• TBD