Computational and Quantitative Biology PhD

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    Davide Bedognetti -Systems biology as a compass to understand tumor-immune interactions in humans

     Registration Closed
    Date: Wednesday, 2nd February 2022 15:00

    Venue: Webex


    Cancer progression is influenced by complex interactions between cancer cell, the immune system, and the microbiome. Deciphering this interplay is critical to develop novel therapeutic approaches and more efficient stratification systems. We use systems biology approaches to dissect the relationship between cancer-cell intrinsic (somatic) and host-related modifiable (microbiome) and unmodifiable (germline genetics) factors with tumor immune responsiveness. In the TCGA, we observed that a significant proportion of immune microenvironmental features are influenced by the genetic background of the host and identified potential drivers of this phenomenon. Furthermore, we assembled a genomic dataset (AC-ICAM) that combines paired tumor-normal whole exome, tumor transcriptome, deep T Cell Receptor sequencing of tumor samples, and tumor-normal colon tissue microbiome characterization. Using such as resource, unreported cancer-immune-microbiome interactions associated with favorable outcome were observed.



    Dr. Davide Bedognetti, MD, PhD is the Director of the Human Immunology Department and Cancer Program at Sidra Medicine. He also serves as an Adjunct Associate Professor at the Hamad Bin Khalifa University in Doha, Qatar, and as an Associate Professor of Internal Medicine at the University of Genova, Italy. Dr. Bedognetti joined Sidra in 2014. Dr. Bedognetti joined Sidra in 2014. He received his MD and PhD in Clinical and Experimental Oncology and Hematology from the University of Genoa, Italy. After obtaining the Board Certification in Medical Oncology by the University of Genova and Italian National Cancer Institute (IST) in 2008, he joined the Infectious Disease and Immunogenetics Section (IDIS, Dr. Marincola’s Lab) of the US National Institutes of Health (NIH) where he completed his post-doctoral fellowship. From 2013 to 2014, he served as Director of the Federation of Clinical Immunology Societies (FOCIS) Center of Excellence at NIH Clinical Center. Dr. Bedognetti is a Group Chair of the Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Committee. He is the Editor of the Cancer Microenvironment Section of the Journal of Translational Medicine (Springer Nature), and Editorial Board Member of Scientific Reports (Nature Research) and Cancer Treatment Reviews (Elsevier). The main focus of Dr. Bedognetti's Lab is to define determinants of immune responsiveness in tumors by using integrative genomic approaches. The ultimate goal is to develop novel and personalized therapeutic strategies. The team employs systems biology approaches to dissect the molecular network of host-tumor interactions, and to understand its relationship with treatment effectiveness. They use samples from clinical studies as starting point of their analyses. The research develops around the following themes : i) identification of germline and somatic genetic determinants of cancer immune responsiveness, ii) implementation of genomic pipelines and biobanking to guide treatment selection, iii) harmonization of multi-omics approaches for the identification of non-invasive prognostic, predictive and mechanistic biomarkers, and iv) development of proof-of-principle in vitro studies for the implementation of advanced immunotherapeutic approaches. He has published more than 100 peer-reviewed articles. Dr Bedognetti’s research has been published in journals such as Immunity, Cell, Cancer Cell, Nature, Nature Cancer, and Nature Communications.




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    • Wednesday, 2nd February 2022 15:00

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